Topological network alignment uncovers biological function and phylogeny

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Topological network alignment uncovers biological function and phylogeny.

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology and disease. Comparison and alignment of biological networks will probably have a similar impact. Existing network alignments use information external to the networks, such as sequence, because no good algorithm for purely topological alignment has yet been devised. In this paper, we present ...

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Local Topological Signatures for Network-Based Prediction of Biological Function

In biology, similarity in structure or sequence between molecules is often used as evidence of functional similarity. In protein interaction networks, structural similarity of nodes (i.e., proteins) is often captured by comparing node signatures (vectors of topological properties of neighborhoods surrounding the nodes). In this paper, we ask how well such topological signatures predict protein ...

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MOTIVATION Network alignment (NA) aims to find regions of similarities between species' molecular networks. There exist two NA categories: local (LNA) and global (GNA). LNA finds small highly conserved network regions and produces a many-to-many node mapping. GNA finds large conserved regions and produces a one-to-one node mapping. Given the different outputs of LNA and GNA, when a new NA metho...

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ژورنال

عنوان ژورنال: Nature Precedings

سال: 2009

ISSN: 1756-0357

DOI: 10.1038/npre.2009.4089.1